# PRNP E200K Research Report

**Protein:** PRNP E200K
**Variant:** E200K
**UniProt ID:** P04156
**Disease Association:** Prion disease (CJD, FFI, GSS)
**Report Generated:** 2026-07-29 21:38 UTC
**AlphaFold Confidence (pLDDT):** 62.5%
**Structure Folded:** 2026-07-29

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## Structure Summary

No structural summary available.

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## Clinical Data

### ClinVar

Not found in ClinVar.

### gnomAD Population Data
- **Allele Frequency:** 8.89e-06
- **Allele Count:** 13
- **Allele Number:** 1461878

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## Open Targets Disease Associations

| Disease | Score | Data Sources |
|---------|-------|--------------|
| Gerstmann-Straussler-Scheinker syndrome | 0.826 | literature, animal_model, genetic_association, genetic_literature |
| Creutzfeldt Jacob disease | 0.786 | literature, animal_model, genetic_association, genetic_literature |
| Huntington disease-like 1 | 0.755 | literature, animal_model, genetic_association, genetic_literature |
| fatal familial insomnia | 0.721 | literature, animal_model, genetic_association, genetic_literature |
| inherited Creutzfeldt-Jakob disease | 0.720 | literature, animal_model, genetic_association, genetic_literature |
| dementia | 0.511 | literature, genetic_literature |
| neurodegenerative disease | 0.508 | literature, affected_pathway |
| hereditary disease | 0.492 | literature, genetic_association |
| prion disease | 0.480 | literature, animal_model, genetic_association, genetic_literature |
| cerebral amyloid angiopathy | 0.479 | literature, genetic_association |

*...and 2180 more associations*

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## Agent Findings

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*Generated by [Clarity Protocol](https://clarityprotocol.io)*

**Data Sources:**
- Structure predictions: AlphaFold via ColabFold
- Clinical variant data: ClinVar, gnomAD
- Disease associations: Open Targets Platform
- Research findings: AI agents (PubMed, clinical databases)