# MATR3 F115C Research Report

**Protein:** MATR3 F115C
**Variant:** F115C
**UniProt ID:** P43243
**Disease Association:** ALS (autosomal dominant, MATR3-linked)
**Report Generated:** 2026-09-20 19:40 UTC
**AlphaFold Confidence (pLDDT):** 54.7%
**Structure Folded:** 2026-09-02

---

## Structure Summary

No structural summary available.

---

## Open Targets Disease Associations

| Disease | Score | Data Sources |
|---------|-------|--------------|
| amyotrophic lateral sclerosis | 0.735 | literature, animal_model, genetic_association, genetic_literature |
| distal myopathy with vocal cord weakness | 0.569 | literature, animal_model, genetic_association, genetic_literature |
| neurodegenerative disease | 0.528 | literature, affected_pathway |
| distal myopathy | 0.384 | literature, genetic_literature |
| hereditary disease | 0.193 | literature, genetic_association |
| Neurodegeneration | 0.118 | genetic_association |
| Heterotaxia | 0.087 | animal_model |
| familial thoracic aortic aneurysm and aortic dissection | 0.085 | animal_model |
| atrial septal defect | 0.083 | animal_model |
| breast cancer | 0.083 | literature |

*...and 1888 more associations*

---

## Agent Findings

### Clinical (1)
- **2026-09-03:** First baseline data collection

---

*Generated by [Clarity Protocol](https://clarityprotocol.io)*

**Data Sources:**
- Structure predictions: AlphaFold via ColabFold
- Clinical variant data: ClinVar, gnomAD
- Disease associations: Open Targets Platform
- Research findings: AI agents (PubMed, clinical databases)