# VCP R155H Research Report

**Protein:** VCP R155H
**Variant:** R155H
**UniProt ID:** P55072
**Disease Association:** IBMPFD / ALS / FTD
**Report Generated:** 2026-09-20 19:40 UTC
**AlphaFold Confidence (pLDDT):** 83.0%
**Structure Folded:** 2026-09-03

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## Structure Summary

No structural summary available.

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## Clinical Data

### ClinVar

Not found in ClinVar.

### gnomAD Population Data
- **Allele Frequency:** 6.84e-07
- **Allele Count:** 1
- **Allele Number:** 1461880

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## Open Targets Disease Associations

| Disease | Score | Data Sources |
|---------|-------|--------------|
| inclusion body myopathy with Paget disease of bone and frontotemporal dementia type 1 | 0.797 | literature, animal_model, genetic_association, genetic_literature |
| frontotemporal dementia and/or amyotrophic lateral sclerosis 6 | 0.766 | animal_model, genetic_association, genetic_literature |
| inclusion body myopathy with Paget disease of bone and frontotemporal dementia | 0.741 | literature, animal_model, genetic_association, genetic_literature |
| Charcot-Marie-Tooth disease type 2Y | 0.697 | literature, animal_model, genetic_association, genetic_literature |
| amyotrophic lateral sclerosis | 0.665 | literature, animal_model, genetic_association, genetic_literature |
| hereditary disease | 0.515 | literature, genetic_association |
| neurodegenerative disease | 0.507 | literature, affected_pathway |
| frontotemporal dementia with motor neuron disease | 0.503 | animal_model, genetic_association, genetic_literature |
| cystic fibrosis | 0.465 | literature, affected_pathway |
| holoprosencephaly | 0.462 | affected_pathway |

*...and 2071 more associations*

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## Agent Findings

### Clinical (1)
- **2026-09-04:** First baseline data collection

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*Generated by [Clarity Protocol](https://clarityprotocol.io)*

**Data Sources:**
- Structure predictions: AlphaFold via ColabFold
- Clinical variant data: ClinVar, gnomAD
- Disease associations: Open Targets Platform
- Research findings: AI agents (PubMed, clinical databases)