MATR3 F115C

01/3D Structure

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? About the 3D Viewer

Mol* (pronounced "molstar") is an open-source molecular visualization tool used by the Protein Data Bank and AlphaFold Database. Learn more at molstar.org.

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What am I looking at?

This is a predicted 3D structure of the protein. The ribbon diagram shows the protein backbone—helices appear as coils, sheets as arrows, and loops as simple lines. The shape determines how the protein functions: where it binds to other molecules, how it catalyzes reactions, and how mutations might disrupt its activity.

Color legend:

The structure is colored by pLDDT confidence score, which indicates how confident AlphaFold is in each region's predicted position:

Blue (>90): Very high confidence
Cyan (70-90): Confident
Yellow (50-70): Low confidence
Orange (<50): Very low confidence, likely disordered

02/AI Analysis

AI summary not yet generated. Check back soon.

03/Research Data

Not found in ClinVar

No population data available

amyotrophic lateral sclerosis

0.74

literature: 0.93 animal model: 0.45 genetic association: 0.85 genetic literature: 0.55

distal myopathy with vocal cord weakness

0.57

literature: 0.14 animal model: 0.26 genetic association: 0.69 genetic literature: 0.61

neurodegenerative disease

0.53

literature: 0.05 affected pathway: 0.87

distal myopathy

0.38

literature: 0.49 genetic literature: 0.61

hereditary disease

0.19

literature: 0.01 genetic association: 0.32

Showing 5 of 1898 associations

Research brief will be generated when agent findings are available.

04/AlphaFold Metrics

No visualization images available.

05/Domain Annotations

Structural Domains & Regions

residues 398–473 Domain — RRM 1

residues 496–571 Domain — RRM 2

residues 801–832 Zinc finger — Matrin-type

residues 146–174 Region — Disordered

residues 187–214 Region — Disordered

residues 342–394 Region — Disordered

residues 588–786 Region — Disordered

residues 710–718 Motif — Nuclear localization signal

residues 160–174 Compositional bias — Basic and acidic residues

residues 201–214 Compositional bias — Basic and acidic residues

residues 600–643 Compositional bias — Basic and acidic residues

residues 653–665 Compositional bias — Acidic residues

residues 666–676 Compositional bias — Low complexity

residues 689–704 Compositional bias — Basic and acidic residues

residues 767–780 Compositional bias — Basic and acidic residues

Binding Partners

RASD1 (6 experiments)

TARDBP (6 experiments)

RBM45 (5 experiments)

HNRNPK (4 experiments)

HTT (4 experiments)

DISC1 (3 experiments)

KRT27 (3 experiments)

KRT34 (3 experiments)

PCBP3 (3 experiments)

Gene Ontology

membrane GO:0016020 nuclear inner membrane GO:0005637 nuclear matrix GO:0016363 nucleus GO:0005634 identical protein binding GO:0042802 miRNA binding GO:0035198 RNA binding GO:0003723 structural molecule activity GO:0005198 zinc ion binding GO:0008270 activation of innate immune response GO:0002218 heart valve development GO:0003170 innate immune response GO:0045087 post-transcriptional regulation of gene expression GO:0010608 ventricular septum development GO:0003281

06/Structural Caption

Structured caption not yet generated. Check back after the next fold analysis.

07/Peptide Therapeutics

Aggregation Analysis

Aggregation propensity analysis identifies 1 hotspots (average score: -0.08) using Pawar+KyteDoolittle+charge algorithm.

Residues 575–579 (0.62)

08/Known Inhibitors

Known Binders from ChEMBL

CHEMBL5653589 Kd: 22.66 nM (pChEMBL 7.64)

CHEMBL5653589

CHEMBL1232461 IC50: 160.0 nM (pChEMBL 6.8)

MOLIBRESIB

CHEMBL3752910 Kd: 30972.89 nM (pChEMBL 4.51)

CHEMBL3752910

09/Candidate Peptides

De Novo Peptide Design Pipeline

Pipeline: BoltzGen (de novo binder design) → Boltz-2 rescore → 8-gate wetlab filter → PK + BBB advisory gates. Target site selected from UniProt curated annotations, P2Rank pocket prediction, and aggregation propensity (in that priority order). Advisory gates annotate each candidate with estimated serum half-life, renal/immunogenicity risk, and (for CNS targets) a recommended blood-brain-barrier shuttle conjugation — without silently dropping designs.

Loading candidate statistics...

Sequences are withheld pending IP review. Full candidate data (sequences, scores, CIF files) is available to authorized reviewers via the /api/private/candidates/{fold_id} endpoint with X-Private-Key.

Legacy candidates (charge-complementary)

Target Region

Residues 575–579 (0.62 aggregation score)

Candidate ID

CP-MATR3-001 (7 residues · computational design)

⚠ Drug-likeness concerns Stability: low | Toxicity: low

t½ ≈ 6 min renal high ⚙ mods suggested peripheral target

10/Agent Findings

Clinical: 1 Peptides: 1

Clinical Agent (1)

First baseline data collection

Peptide Agent (1)

MATR3 F115C: 3 known binders (top: 22.7 nM); 1 candidate peptides designed